Marijuana can disrupt fertility in males, but it can also be a therapeutic strategy for treating male infertility as researchers show that a cannabinoid receptor, called “CB2,” helps regulate the creation of sperm.
“The possibility to improve male fertility is one of the main focuses of this study, since infertility is a worldwide problem that affect up to 15% of couples in which male factors account for almost 20-70%,” said Paola Grimaldi, a researcher involved in the work from the Department of Biomedicine and Prevention, School of Medicine at the University of Rome Tor Vergata in Rome, Italy.
‘Cannabinoid receptor or CB2 activator showed an acceleration of spermatogenesis, which may help in development of newer treatments for male infertility.
To make their discovery, Grimaldi and colleagues treated three groups of mice with different agents for 14 to 21 days. The first group was treated with a specific activator of the CB2 receptor. The second group was treated with a specific inhibitor of the CB2 receptor. The third group received only a saline solution and served as the control group.
The group treated with the CB2 activator showed an acceleration of spermatogenesis, while the group treated with the inhibitor displayed a slower rate of the process. This suggests that a tight balance of CB2 activation is required for the proper progression of spermatogenesis.
“That the normal beneficial effects of endogenous cannabinoids on spermatogenesis can be stimulated further by a chemical mimic, an agonist, is a potentially promising new idea for treating male infertility,” said Thoru Pederson, Editor-in-Chief of The FASEB Journal.